I've seen different ways to play this song on the guitar with chords but they just don't appeal to me. So I made one that follows the syllables of the words of the whole song.

^CTwink^Cle, ^Gtwin^Gkle, ^Amlittl^Ame st^Car ^FHow ^FI ^Cwond^Cer w^Ghat y^Gou a^Cre.

^CUp ^Cabo^Fve t^Fhe w^Corld ^Cso ^Ghigh ^CLike ^Ca d^Fiam^Fond i^Cn t^Che s^Gky

^CTwink^Cle, ^Gtwin^Gkle, ^Amlitt^Amle ^Cstar ^FHow ^FI ^Cwon^Cder w^Ghat y^Gou a^Cre!

Every chord displayed in this "guide" is just one strum downwards. This is to follow the syllables.

Misc Children - Twinkle twinkle little star